He takes over from Brian Carey as manager with Carey assisting the new man.
"I'm delighted to be joining Wrexham," Little told the club's official website.
"I think the most important thing is to sort out the team's position in the league. Then and only then can you look to the future.
"It might take a little time and maybe it will be a long hard season, but we've got to have a focus on trying to get away from the bottom of the table."
His first game in charge will be the local derby with Chester on November 25th.