The Scotland international has been included in Martin O'Neill's first XI only five times since his £1 million move from Celtic in January.
O'Neill has insisted Maloney is staying at Villa despite the player admitting to still being homesick.
The threadbare nature of O'Neill's squad means he can make few changes although Marlon Harewood, Gary Cahill and Luke Moore in addition to Maloney could be given a start if he decides to freshen up the team.
Steve Evans and Mark Jones look set to celebrate their international call-ups by returning to the Wrexham team.
Defender Evans and midfielder Jones have been named in Josh Toshack's squad to play Germany and Slovakia in the European Championship qualifiers next month and Wrexham manager Brian Carey will pick them in his starting XI after they featured from the substitutes' bench in Saturday's defeat at Bradford.
Elsewhere, Eifion Williams has been passed fit following his calf strain but Trinidad and Tobago midfielder Silvio Spann has yet to receive international clearance despite being granted a work permit.
The Welsh outfit will be hoping to continue their cup run after claiming the scalp of League One side Port Vale on penalties in the first round.
Aston Villa (from): Carson, Taylor, Gardner, Mellberg, Laursen, Bouma, Young, Petrov, Reo-Coker, Barry, Agbonlahor, Carew, Moore, Cahill, Harewood, Maloney, Osbourne.
Sporting Life