Oxford United 1 Wrexham 0
Wrexham were cruelly denied a share of the spoils from this entertaining encounter when James Constable headed a last gasp winner in time added on.
There were more changes to the line up, Curtis and Williamson were restored to a five man defence, alongside Westwood, Williams and Assoumani.
The first chance of the match fell to Constable on eleven minutes, Odubade's cross was met by the striker, but his header was wide. Wrexham were creating very little up front, while at the other end, their usually shaky defence was coping with the Oxford threat comfortably.
The only danger in the rest of the first period came from a couple of dangerous crosses, which were dealt with by Williams and Westwood respectively.
The second period started in much the same vein with Oxford doing most of the pressing. Nielsen had to be alert, coming off his line to claim two high crosses. Then on 53 minutes, Haldane tried his luck from 25 yards, again Nielsen was equal to it, this time tipping the shot away for a corner.
Wrexham were beginning to dominate possession, without creating any clear cut chances, but some fine play between Curtis and Flynn gave the full back an opportunity, but he dragged his shot inches wide.
There was another scare for Wrexham after 72 minutes, when Constable got behind Westwood, his header fell to Murray but his effort cleared the crossbar.
Obi Anoruo had a claim for a penalty turned down and was looking lively up front for Wrexham, But on seventy five minutes Wrexham were dealt a blow when Goalkeeper Nielsen had to leave the field after injuring his hand when punching a cross clear.
Collin came on as Substitute with Westwood taking over between the posts. Wrexham continued to press forward, Flynn made a good run through the middle but his chip found the side netting. Anoruo also had a half chance which Turley dealt with.
Just when it looked like Wrexham would get some reward for all their efforts, they were punished deep into stoppage time. A cross by Nelthorpe was met by Constable, his header crashed in off the underside of the bar with Westwood stranded.
It was a cruel blow for the Dragons, who deserved much better from a very spirited and determined performance.